How Long Does It Take for The Sinclair Method to Work?

Key Takeaways

• Early changes in cravings and habits may begin within the first few weeks of starting The Sinclair Method (TSM)

• Most people see noticeable reductions in drinking after 3 to 6 months

• Full pharmacological extinction can take 6 to 12 months or more

• Consistency, drinking patterns, and support systems all impact the timeline

• The method is flexible, allowing individuals to reach their own version of success — whether it's moderation or abstinence

The Sinclair Method (TSM) is gaining traction as a science-backed way to change our relationship with alcohol without relying on willpower alone. But a common and completely valid question we get is: how long does it take for The Sinclair Method to work? The answer isn’t one-size-fits-all — but there are clear stages of progress and key factors that influence how quickly you’ll see results.

Whether you're new to TSM or you're weeks in and wondering what to expect, let’s walk through the timeline together and set realistic, motivating expectations.

What to Expect in the First Few Weeks

When starting TSM, most people begin by taking naltrexone — a non-addictive, opioid-blocking medication — one hour before drinking alcohol. This is the heart of the method: blocking the brain’s reward from alcohol so, over time, the craving fades through a process called pharmacological extinction.

During the first few weeks:

• You may start noticing a slight reduction in cravings

• Drinking may start to feel more intentional instead of automatic

• Some people feel more in control during drinking episodes

• Others report thinking about alcohol less frequently

However, this early phase is just the beginning. Think of it as your brain starting to "relearn" that alcohol doesn’t produce the same buzz it used to. That learning takes repetition and time.

What Progress Looks Like After 3–6 Months

If you’re consistent with your medication — meaning you take it before every drink — many people begin to see more measurable results within three to six months:

• Fewer heavy drinking days

• Lower alcohol consumption overall

• More alcohol-free days (without effort or pressure)

• Some people begin to skip drinks simply because they don’t feel like it

During this time, we often hear from people who start to question their old drinking patterns. The desire to drink “just because” begins to weaken. This is a crucial turning point and shows that the brain is adjusting to the medication's effects.

Want to understand how this works on a deeper level? We recommend watching the documentary One Little Pill, which explores the science behind TSM and features real people sharing their recovery journeys.

When Pharmacological Extinction Occurs (6–12 Months+)

“Pharmacological extinction” is the point where alcohol no longer triggers the same intense cravings or reward in the brain. Many people describe it as alcohol feeling neutral. You can take it or leave it — and for some, that means drinking socially and occasionally. For others, it means they naturally stop drinking altogether.

This level of transformation generally happens between 6 and 12 months. In some cases, it might take longer, especially if:

• You’ve been drinking heavily for many years

• You drink less frequently (fewer learning opportunities for the brain)

• You’ve struggled with consistency in taking the medication properly

But don’t worry — the process works, even if it takes a little more time. It’s not about perfection. It’s about progress.

Factors That Affect How Quickly The Sinclair Method Works

Several key factors influence how long it takes for TSM to show results:

• Consistency: Taking naltrexone before every drinking occasion is critical. Skipping doses can stall progress.

• Frequency of drinking: Ironically, drinking more often (while following the method correctly) can accelerate extinction — more chances for the brain to rewire.

• Length and severity of alcohol use: Long-standing or severe alcohol use disorder (AUD) may require more time.

• Support systems: Coaching, community, and addressing emotional or mental health challenges can make a big difference.

• Lifestyle habits: Improvements in sleep, nutrition, and stress reduction support recovery on every level.

For personalised support, we encourage you to explore our resources and coaching options over on the Rethink Drink homepage. We’re here to walk with you through each phase of change.

The Beauty of Going at Your Own Pace

One of the things we love most about The Sinclair Method is its flexibility. You don’t have to quit drinking overnight. You don’t even have to know exactly what your end goal is yet.

This method meets you where you are. Whether you’re aiming for mindful moderation or freedom from alcohol altogether, TSM allows your brain and body to make that shift organically — without shame, guilt, or unnecessary pressure.

Want to see the difference in real life? Many people share that at around 9 to 12 months in, they no longer feel “hooked” by alcohol. They simply enjoy their lives — sometimes with a drink, often without. And for many, that’s freedom.