Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Ozempic and naltrexone are very different medications, each targeting distinct areas of the brain and body. Ozempic is designed to manage type 2 diabetes and promote weight loss by reducing hunger. Naltrexone is specifically designed to reduce cravings and the rewarding effects of alcohol.
When we talk about recovery from alcohol use disorder (AUD), most people still think of abstinence — the complete and permanent cessation of drinking. It's the traditional approach taken by many rehab centres and support groups like Alcoholics Anonymous.
That’s where The Sinclair Method (TSM) shines. This innovative approach offers an alternative: gradual reduction, using the medication naltrexone to change your brain’s response to alcohol, one drink at a time.
The Sinclair Method (TSM) has emerged as a ground-breaking approach to reducing alcohol consumption through a medication-first strategy. By using Naltrexone to disrupt the brain’s reward cycle, it gradually helps people lose interest in alcohol.
The Sinclair Method, often referred to as TSM, has quietly revolutionised how we understand and treat Alcohol Use Disorder (AUD). Unlike traditional abstinence-only approaches, it offers a scientifically grounded, compassion-driven alternative. But where did it all begin?
At Rethink Drink, we're proud to be leading the charge in reshaping how the UK approaches alcohol recovery. For too long, individuals seeking change have faced limited choices: abstinence-only programmes, rigid systems, and shame-based narratives. We exist to offer a smarter, science-backed alternative — The Sinclair Method (TSM).