Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
Ozempic vs Naltrexone: Understanding the Key Differences for Alcohol Recovery
Bruce Rose Published on: 16/09/2025
Ozempic and naltrexone are very different medications, each targeting distinct areas of the brain and body. Ozempic is designed to manage type 2 diabetes and promote weight loss by reducing hunger. Naltrexone is specifically designed to reduce cravings and the rewarding effects of alcohol.
The Sinclair Method (TSM)
The Sinclair Method vs Abstinence: Which Path to Recovery is Right for You?
Bruce Rose Published on: 15/09/2025
When we talk about recovery from alcohol use disorder (AUD), most people still think of abstinence — the complete and permanent cessation of drinking. It's the traditional approach taken by many rehab centres and support groups like Alcoholics Anonymous.
The Sinclair Method (TSM)
Could This £3 Pill Be the Answer? What Recent Newspapers Are Saying About Naltrexone and The Sinclair Method
Bruce Rose Published on: 05/09/2025
Over the past few months, major UK tabloids like The Sun have published several high-profile stories on naltrexone — a £3 tablet nicknamed the "Ozempic for drinkers". It’s been hailed by some as a revolutionary option for those wanting to cut back or quit alcohol.
The Sinclair Method (TSM)
Does The Sinclair Method Work? Exploring Its Success and Science
Bruce Rose Published on: 04/09/2025
The Sinclair Method (TSM) is a medication-based treatment for Alcohol Use Disorder (AUD) that allows individuals to continue drinking while retraining their brain’s response to alcohol. The cornerstone of this method is naltrexone, an opioid blocker that dulls the endorphin rush typically triggered by alcohol.
The Sinclair Method (TSM)
Dr David Sinclair: The Research Legacy Behind The Sinclair Method
Bruce Rose Published on: 11/06/2025
The Sinclair Method didn’t originate in a corporate lab or a detox facility—it started in a Helsinki research centre. Dr John David Sinclair, a behavioural psychologist from the United States, moved to Finland in the early 1970s after completing his PhD. There, he joined Alko Laboratories, the research arm of Finland’s state alcohol monopoly, which would later become part of the country’s National Public Health Institute.
The Sinclair Method (TSM)
Is Naltrexone Available in the UK and Ireland? What You Need to Know
Bruce Rose Published on: 28/05/2025
Naltrexone is a non-addictive opioid antagonist that blocks the brain’s ability to feel pleasure from alcohol. Over time, drinking becomes less rewarding, reducing cravings and consumption naturally — a process known as Pharmacological Extinction. This effect is the foundation of The Sinclair Method (TSM), where individuals take Naltrexone only prior to drinking, gradually reprogramming their brain’s response to alcohol.
The Sinclair Method (TSM)
