Does The Sinclair Method Work? Exploring Its Success and Science

Key Takeaways

• The Sinclair Method (TSM) uses targeted naltrexone to reduce alcohol cravings over time.

• Clinical studies show a 70–80% success rate for reducing alcohol consumption or achieving pharmacological extinction.

• Success relies on strict adherence to taking naltrexone before every drinking session.

• TSM offers an alternative to abstinence-based recovery by supporting controlled drinking.

• Tools like coaching and structured support dramatically improve outcomes.

Understanding the Sinclair Method

The Sinclair Method (TSM) is a medication-based treatment for Alcohol Use Disorder (AUD) that allows individuals to continue drinking while retraining their brain’s response to alcohol. The cornerstone of this method is naltrexone, an opioid blocker that dulls the endorphin rush typically triggered by alcohol.

When naltrexone is taken one hour before drinking, it blocks the pleasure receptors in the brain. Over time, with repeated use, the brain unlearns the association between alcohol and reward—a process known as pharmacological extinction.

Unlike traditional abstinence-based programmes, TSM aims for behavioural extinction rather than forced willpower. For many, it becomes a powerful alternative that reduces cravings without demanding immediate sobriety.

Does It Really Work? Evidence-Based Results

TSM isn't just a novel idea—it’s backed by decades of research. The method was developed by Dr David Sinclair, who demonstrated that alcohol-related reward pathways could be weakened through targeted opioid antagonism.

Clinical Success Rates

• Dr Sinclair’s research (2001): Showed a 78% success rate, with participants reaching extinction in 3–4 months.

• Rethink Drink UK: Reports that 78% of users see meaningful reductions in drinking and cravings.

These findings are consistent across multiple studies and real-world use. The core factor? Following the method properly.

Why Adherence Matters

The biggest caveat to The Sinclair Method is simple: you must take the medication before every drinking occasion. Skipping a dose or drinking without the blocker can reinforce the alcohol-reward loop, undermining progress.

That’s why structured support, guidance, and accountability are vital. Our Sinclair Method coaching and support at Rethink Drink is designed to help you stay consistent, troubleshoot challenges, and move steadily toward extinction.

The Science Behind Pharmacological Extinction

TSM operates through a process rooted in neuroscience:

• Take naltrexone one hour before drinking.

• Naltrexone blocks the endorphins triggered by alcohol.

• The brain no longer associates alcohol with reward.

• Over time, cravings decrease naturally.

• Drinking becomes less compulsive and more conscious.

Most individuals see changes within 1–3 months, though it can take longer depending on the person’s drinking history and biological makeup.

Is It Right for You?

While TSM has a high success rate, it's not ideal for everyone. It tends to work best for those who:

• Want to reduce or quit drinking but aren’t ready for full abstinence.

• Have tried abstinence-based methods without lasting success.

• Are willing to follow a structured protocol consistently.

• Prefer a private, medication-led approach without group therapy.

• Have no major contraindications for naltrexone (e.g. liver conditions).

Not sure if you’re a good fit? You can book a free screening call to discuss your options with a member of our team.

Advantages and Drawbacks of TSM

Pros:

• Offers flexibility—no need for immediate abstinence.

• Backed by decades of clinical research.

• Reduces cravings without relying on willpower.

• Can be done discreetly from home.

• Empowers individuals to regain control at their own pace.

Cons:

• Requires consistency—naltrexone must be taken before every drinking session.

• May cause side effects initially (e.g. nausea, headache, sleep issues).

• Not suitable for people with specific medical conditions.

• Doesn’t offer immediate detox.

To decide whether TSM aligns with your goals, we recommend exploring our free video mini-course on the Sinclair Method, which outlines how the approach works in detail.

Tips for Success on the Sinclair Method

• ✅ Take naltrexone exactly one hour before drinking.

• ✅ Keep a journal to track drinks, cravings, and emotional triggers.

• ✅ Use support systems or coaching to stay on track.

• ✅ Don’t rush—let the brain adjust gradually.

• ✅ Stick with the programme for at least 3–4 months to evaluate progress.

Many people report that cravings start to fade within weeks—but full extinction often takes longer. Patience and consistency are key.

Final Thoughts

So, does the Sinclair Method work? Absolutely—if followed correctly. For those who want an alternative to abstinence and are willing to commit to the protocol, TSM offers a well-researched, empowering route to freedom from alcohol dependence.

With over 70–80% of users reporting success, it’s a method that’s giving new hope to people across the world. If you’re tired of fighting cravings and want a different path forward, the Sinclair Method could be exactly what you’ve been looking for.