Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
The Sinclair Method (TSM) is a medically backed approach that uses targeted medication, specifically Naltrexone, to reduce alcohol cravings over time. The principle is simple: take Naltrexone one hour before drinking, and gradually, your brain unlearns the alcohol-reward connection.
It’s a common concern: Am I drinking too much? And with good reason. While 14 units per week is the current UK guideline for low-risk drinking, what really matters is how alcohol fits into your lifestyle and mental health.