Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
A look into what The Sinclair Method is, and how it can help you finally get a handle on your drinking.
At Rethink Drink, we're proud to be leading the charge in reshaping how the UK approaches alcohol recovery. For too long, individuals seeking change have faced limited choices: abstinence-only programmes, rigid systems, and shame-based narratives. We exist to offer a smarter, science-backed alternative — The Sinclair Method (TSM).
The Sinclair Method (TSM) is a medication-based treatment for Alcohol Use Disorder (AUD) that allows individuals to continue drinking while retraining their brain’s response to alcohol. The cornerstone of this method is naltrexone, an opioid blocker that dulls the endorphin rush typically triggered by alcohol.
The Sinclair Method (TSM) is a medically proven approach to reducing and overcoming alcohol dependence – one that flips conventional treatment on its head. Rather than asking you to quit drinking from day one, TSM invites you to do something far simpler: take a tablet of naltrexone one hour before drinking.
When you're navigating alcohol use disorder (AUD), few things are more powerful than hearing from someone who's been where you are—and found a way out. At Rethink Drink, we're proud to share real, verified success stories for The Sinclair Method (TSM) as experienced by our clients.
Naltrexone is a prescription medication used to reduce the desire to drink by blocking endorphins released when alcohol is consumed. This means individuals no longer receive the same “buzz” from drinking, which over time leads to a reduction in cravings and overall consumption.