Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
The Sinclair Method (TSM) is a medically proven approach to reducing and overcoming alcohol dependence – one that flips conventional treatment on its head. Rather than asking you to quit drinking from day one, TSM invites you to do something far simpler: take a tablet of naltrexone one hour before drinking.
When you're navigating alcohol use disorder (AUD), few things are more powerful than hearing from someone who's been where you are—and found a way out. At Rethink Drink, we're proud to share real, verified success stories for The Sinclair Method (TSM) as experienced by our clients.
Naltrexone is a prescription medication used to reduce the desire to drink by blocking endorphins released when alcohol is consumed. This means individuals no longer receive the same “buzz” from drinking, which over time leads to a reduction in cravings and overall consumption.
The Sinclair Method (TSM) is a medically supported approach to reducing alcohol dependence through the use of Naltrexone, an opioid antagonist that blocks the pleasurable effects of alcohol. Unlike traditional abstinence-based models, TSM allows individuals to continue drinking while rewiring their brain’s reward system over time.