Sinclair Method Studies
Published on: 11/06/2025
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.
For many, the word “detox” brings up images of cold-turkey abstinence, withdrawal symptoms, and white-knuckled willpower. But what if we told you that there’s a method that flips this idea on its head?
Naltrexone is a prescription-only medication approved to help treat alcohol dependence in Ireland. It works by blocking the brain’s opioid receptors, reducing the sense of pleasure from alcohol. This dampens the reward cycle and gradually lessens alcohol cravings.