Does The Sinclair Method Work? A Closer Look Compared to Abstinence-Based Recovery

Published on: 25/03/2025

The Sinclair Method is a form of medication-assisted treatment that uses opioid-blocking medication—typically naltrexone or nalmefene—to retrain the brain’s response to alcohol. The method is based on a process called pharmacological extinction, which reduces the reward associated with alcohol over time.

The Sinclair Method (TSM)