Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.

The Sinclair Method, often referred to as TSM, has quietly revolutionised how we understand and treat Alcohol Use Disorder (AUD). Unlike traditional abstinence-only approaches, it offers a scientifically grounded, compassion-driven alternative. But where did it all begin?

The Sinclair Method is a form of medication-assisted treatment that uses opioid-blocking medication—typically naltrexone or nalmefene—to retrain the brain’s response to alcohol. The method is based on a process called pharmacological extinction, which reduces the reward associated with alcohol over time.

Let's delve into a comparison of their effectiveness, focusing on the physical, emotional, and psychological dimensions of recovery.
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