Blog Image

Sinclair Method Studies

Published on: 11/06/2025

This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.

Understanding the Sinclair Method: A Neurological Approach to Alcohol Recovery

Understanding the Sinclair Method: A Neurological Approach to Alcohol Recovery

Published on: 02/05/2025

The Sinclair Method is a revolutionary approach to treating Alcohol Use Disorder. Instead of requiring people to stop drinking immediately, it uses a medication — Naltrexone — to help gradually reduce alcohol cravings and dependency. Individuals take Naltrexone one hour before drinking, which blocks the opioid receptors in the brain and, over time, extinguishes the reward response to alcohol.

The Sinclair Method (TSM)
Rethink Drink Footer Logo

Copyright Rethink Drink Ltd 2023-2025 | Company Registration Number 14619896

The Sinclair Method UK | Privacy Policy | FAQ | Login | Free UK Alcohol Units Calculator | What is the Sinclair Method?