Sinclair Method Studies

Published on: 11/06/2025

This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.

Endorphin Addiction: The Link Between Alcohol and the Brain’s Pleasure System

Published on: 06/03/2025

Endorphins are natural opioids produced by the brain that regulate pain and pleasure. When alcohol is consumed, it triggers the release of these endorphins in brain areas linked to reward, such as the nucleus accumbens and orbitofrontal cortex. This release creates feelings of euphoria and relaxation, reinforcing the urge to drink.

NeuroscienceThe Sinclair Method (TSM)

Endorphin Addiction and Alcohol: Understanding the Biology of Alcohol Consumption

Published on: 24/02/2025

The reason alcohol feels rewarding is deeply rooted in brain chemistry. When we drink, alcohol stimulates the release of endorphins, which are the body's natural feel-good chemicals. These endorphins interact with opioid receptors in the brain, producing sensations of euphoria, relaxation, and stress relief.

NeuroscienceThe Sinclair Method (TSM)

The Biochemistry of Alcohol and Endorphins

Published on: 21/03/2024

The consumption of alcohol and the release of endorphins in the brain are intricately linked, creating a biochemical reaction that can influence our feelings of pleasure, pain, and overall well-being

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