Does The Sinclair Method Work? Evidence, Success Rates & What to Expect
Key Takeaways:
Naltrexone has been studied in dozens of clinical trials over several decades. What the research shows explains what they found.
Backed by neuroscience: Naltrexone reduces cravings by interrupting the alcohol-endorphin link
Sustainable approach: Allows continued drinking during treatment, easing the transition
Higher efficacy: Outperforms abstinence-only models, which show only 5–8% success
Comprehensive support: Coaching and personalised guidance available through Rethink Drink
Understanding The Sinclair Method (TSM)
The Sinclair Method (TSM) is a medically supervised treatment for Alcohol Use Disorder (AUD) that utilises the opioid-blocking medication naltrexone. This treatment works by weakening the association between alcohol and the brain’s reward system. Naltrexone is taken one hour before drinking, blocking endorphins that would normally reinforce the behaviour.
Over time, this leads to pharmacological extinction—a process where cravings naturally decline because drinking no longer produces the same pleasurable effects. This approach offers a flexible alternative to the ‘cold turkey’ abstinence model and has been transformative for many.
The Science Behind TSM: 35 Years of Research
Dr David Sinclair pioneered the method after decades of research into how addictive behaviours are formed. His breakthrough discovery revealed that alcohol dependency is a learned behaviour, reinforced by endorphins released during drinking.
Using naltrexone to block these endorphins prevents reinforcement, helping to “unlearn” the addiction over time. The Sinclair Method is:
Based on more than 35 years of global research
Practised extensively in Finland and other parts of Europe
Recognised as a legitimate medical treatment for AUD
Comparative Success Rates: TSM vs. Traditional Methods
When compared to conventional treatment models, The Sinclair Method demonstrates significantly better outcomes:
How well The Sinclair Method works varies from person to person. What the research shows sets out the evidence honestly, including its limits.
Traditional abstinence-based treatments show a success rate of just 5–8%, with many participants relapsing after initial detox
TSM’s approach avoids the cycle of relapse by gradually extinguishing the desire to drink
Clients report increased autonomy, reduced shame, and fewer withdrawal symptoms during the process
These statistics demonstrate that pharmacological extinction is not only effective but often preferred by those who struggle with total abstinence.
How Rethink Drink Supports Your TSM Journey
At Rethink Drink, we specialise in helping individuals throughout the UK use The Sinclair Method to regain control of their drinking. Here’s how we support you:
One-on-one coaching with experienced TSM professionals
Access to naltrexone through trusted prescribers
Ongoing guidance tailored to your personal drinking patterns
Resources like the One Little Pill documentary, which showcases real-life TSM success stories
Book a Free Screening Call to explore if TSM is the right fit for your needs
We believe recovery should be empowering—not intimidating. Our programme is built around your life, not the other way around.
Is The Sinclair Method Right for You?
TSM may be a fit if you:
Have tried abstinence-based programmes without lasting success
Want a gradual, medically guided reduction in alcohol use
Are willing to take naltrexone consistently before drinking
Prefer an evidence-based method with high success rates
Value privacy, flexibility, and non-judgemental support
To find out if you’re eligible, schedule your Free Screening Call today and take the first step toward lasting change.
Final Thoughts
The Sinclair Method has emerged as one of the most promising treatments for Alcohol Use Disorder, offering science-backed success and a refreshingly compassionate approach.
If you're curious about starting your own TSM journey, visit our homepage to discover how Rethink Drink can support you every step of the way.
